For TNF-α signaling, TNF-α and heterogenous nuclear ribonucleoprotein L related immunoregulatory lncRNA (THRIL) forms a self-regulatory circuit where TNF-α induces fat mass and obesity-associated (FTO)-mediated m6A demethylation of THRIL, triggering YTH n6-methyladenosine RNA binding protein 2 (YTHDF2)-dependent degradation to suppress NSCLC proliferation. The gene discussed is TNF; the disease is non-small cell lung carcinoma.