TSC22D3 and colorectal cancer: First, elevated plasma corticosteroid levels and upregulation of the glucocorticoid-induced leucine zipper protein TSC22 domain family protein 3 suppress the type I interferon response in dendritic cells and interferon gamma-producing T cells, thereby impairing immunosurveillance and reducing the efficacy of antitumor therapies in non-small-cell lung cancer and colorectal cancer (81).