Pathological amyloids, such as Aβ in Alzheimer’s (Selkoe, 1991), α-synuclein in Parkinson’s (Goedert et al., 2001), and TDP-43 (Prasad et al., 2019) or FUS in ALS are implicated in neurodegenerative diseases (Takanashi and Yamaguchi, 2014). Here, TARDBP is linked to neurodegenerative disease.