A study employed single‐nucleus ATAC sequencing (snATAC‐seq) to analyze the chromatin accessibility of myofibroblasts in IPF patients as a method to address this issue [100] and revealed significant enrichment of TWIST1 and other E‐box TF motifs in the open chromatin regions of IPF myofibroblasts. The gene discussed is TF; the disease is idiopathic pulmonary fibrosis.