CDKN2A and lung cancer: This supports the hypothesis that reduced CpG methylation may be necessary for histone acetylation at the CDKN2A promoter leading to re-expression of silenced CDKN2A. The finding that demethylation is necessary for effective hyperacetylation by HDACi was also reproduced more recently in lung cancer models, in the context of inducing de novo transcription from cryptic transcription start sites [2].