Over the past decade, several CAFs-derived chemokines such as interleukin-6 (IL-6), C-X-C motif chemokine ligand 12 (CXCL12), and C-C motif chemokine ligand 2 (CCL2) have been implicated in the mechanisms driving tumor progression [13, 19, 20]. Here, CXCL12 is linked to neoplasm.