Among subgroups in the diabetes cohort, compared with the low-tertile subgroup, high-tertile subgroup had significantly higher proportion of type 2 diabetes (93 vs 57%, p = 0.028), lower proportion of type 1 diabetes (7 vs 43%, p = 0.028), higher CRP (p = 0.003), HOMA-IR (p = 0.002), insulin concentrations (p = 0.003), C-peptide levels (p = 0.002), leptin (p = 0.007), adiponectin (p < 0.001), however cortisol values were not different (p = 0.922), Table 2. The gene discussed is LEP; the disease is type 2 diabetes mellitus.