They more frequently required mechanical ventilation (38% vs. 12%, p < 0.05), vasopressors (42% vs. 15%, p < 0.05), and high-dose vasopressors (20% vs. 4%, p < 0.05), and exhibited worse metabolic derangements, including hyperlactatemia (4.5 vs. 2.1 mmol/L, p < 0.05), acidosis (7.25 vs. 7.35, p < 0.05), hyponatremia (52% vs. 44%, p < 0.05), anemia (Hb 9.8 vs. 11.0 g/dL, p < 0.05) and renal impairement (creatinine 5.6 vs. 2.8 mg/dL, p < 0.05), alongside higher severity scores (APACHE II: 26 vs. 14; SOFA: 9.8 vs. 4.1; SAPS II: 50 vs. 32; p < 0.05). This evidence concerns the gene GSTM1 and Hyponatremia.