Univariate analysis (Table 4) revealed significant differences between HT and non-HT groups for multiple factors including age, atrial fibrillation, TOAST classification, infarct volume, admission NIHSS score, creatinine, uric acid, white blood cell count, neutrophil percentage, reperfusion therapy and serum levels of both NLRP3 inflammasome and occludin. The gene discussed is OCLN; the disease is atrial fibrillation.