The final multivariate model (Table 4) demonstrated that infarct volume (adjusted OR 5.53, p = 0.025), renal function (per 1 μmol/L creatinine increase: OR 1.09, p = 0.015), reperfusion therapy (OR 16.23, p = 0.036) and serum NLRP3 inflammasome concentration (per 1 pg/mL increase: OR 1.04, p = 0.001) independently predicted HT risk after cerebral infarction. This evidence concerns the gene NLRP3 and brain infarction.