NOTCH1 and intrahepatic cholangiocarcinoma: HIPPO/YAP1 signalling is also implicated in Ang II-mediated proliferation in intrahepatic cholangiocarcinoma (iCCA), with ARBs disrupting AGTR1+ cancer-associated fibroblast (CAF) MFAP5/Notch1 signalling by impeding YAP/TEAD nuclear translocation and reducing tumour proliferation (Fig. 1) [55].