AGTR1 and neoplasm: Targeted AT1R inhibition-mediated downregulation of the PI3K/AKT/mTOR pathway has a role in reduced proliferation and increased apoptosis in CRC [46], lung [47], kidney [48], ovarian [49], and oesophageal [16] cancers, as demonstrated by reduced cell viability and tumour volume [46], reduced Ki-67 and increased TUNEL staining [47, 48].