5-fluorouracil (5-FU), an inhibitor of DNA synthesis, has shown synergy with valsartan in CRC models, increasing apoptosis, (increased levels of Bax and p53 plus decreased Bcl2 levels found), inhibiting migration (decreased MMP-2 and MMP-9 levels) and reducing tumour burden In vivo, though not as significantly as 5-FU monotherapy. This evidence concerns the gene MMP9 and colorectal carcinoma.