Next, to investigate the commonality of the ISR among cell types, we used confocal imaging to examine whether the rapid accumulation of BMAL1 and CLOCK in the nucleus occurs after Dex stimulation in rodent cells with clock oscillation including rat glioma C617, mouse myoblast C2C1218, and mouse fibroblast MEF cells14 (Supplementary Fig. 3). The gene discussed is CLOCK; the disease is glioma.