The functional significance of ULK1 in tumor progression is further supported by our findings that ULK1 depletion in both mouse (KPC) and human (MIA PaCa-2) pancreatic cancer cells significantly impaired their proliferation and invasion, supporting its role in tumor aggressiveness (Fig. 2 and Supplementary Fig. 3). The gene discussed is ULK1; the disease is familial pancreatic carcinoma.