Moreover, the secreted levels of G-CSF and Ccl2 were notably reduced, but GM-CSF levels were significantly elevated in in CM from Ulk1 KO cells, indicating that Ulk1 determines to regulate tumor-intrinsic G-CSF, Ccl2 and GM-CSF secretion oppositely (Fig. 7a,b). The gene discussed is CCL2; the disease is neoplasm.