By contrast, protumorigenic chemokines Cxcl2 and Ccl2 —known to promote the recruitment of PMN-MDSCs and M2 macrophages42—were markedly reduced in Ulk1 KO cells, consistent with previous immunophenotyping data from pancreatic tissues of spontaneous cancer model (Fig. 7). The gene discussed is CXCL2; the disease is cancer.