PDPN and adenocarcinoma: IHC analysis revealed that cancer-associated fibroblast (CAF) markers (αSMA, PDPN and FAP) and immunosuppressive M2 macrophage marker CD204 were more abundant in tumors from KPC;Ulk1fl/+ control mice, particularly in CK19+ adenocarcinoma lesions, whereas these markers were notably reduced in the pancreas of KPC;Ulk1fl/fl mice (Fig. 5a,b).