To further investigate the role of ULK1 in pancreatic cancer progression, we used the LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx1-Cre (KPC) mouse model33, which spontaneously develops pancreatic tumors that mimic the pathology of human PDAC. Here, PDX1 is linked to familial pancreatic carcinoma.