Diagnostic tools for IBD and IBS range from invasive procedures such as biopsies and colonoscopies to non-invasive tests, including (C-reactive protein) (CRP) and fecal calprotectin However, these non-invasive markers lack specificity, making it difficult to accurately distinguish between gastrointestinal disorders and enhance patient management25,26. The gene discussed is CRP; the disease is irritable bowel syndrome.