PSEN1 and Alzheimer disease: However, when we surveyed sex differences noted in two additional AD mouse lines, the Thy1 driven 3xTg (Table S1) and PrP-dependent APP/PS1 (Table S2), we noted several sex-biased alterations in pathological, physiological, and behavioral endpoints shared across all models (e.g., Aβ accumulation) (Fig. 5).