ITGA4 and rheumatoid arthritis: The intersection of Celastrol-target genes, turquoise module genes, RA differentially expressed genes, and RA-associated genes were taken, and 13 intersecting genes(ADAMTS5, AGTR1, ALOX5, CTSB, MMP3, MMP9, MYC, TNF, ITGA4, ITGB7, MMP1, MMP13, PPARG) were selected as key genes (Fig. 2B).