The intersection of Celastrol-target genes, turquoise module genes, RA differentially expressed genes, and RA-associated genes were taken, and 13 intersecting genes(ADAMTS5, AGTR1, ALOX5, CTSB, MMP3, MMP9, MYC, TNF, ITGA4, ITGB7, MMP1, MMP13, PPARG) were selected as key genes (Fig. 2B). Here, MMP3 is linked to rheumatoid arthritis.