The intersection of Celastrol-target genes, turquoise module genes, RA differentially expressed genes, and RA-associated genes were taken, and 13 intersecting genes(ADAMTS5, AGTR1, ALOX5, CTSB, MMP3, MMP9, MYC, TNF, ITGA4, ITGB7, MMP1, MMP13, PPARG) were selected as key genes (Fig. 2B). The gene discussed is ALOX5; the disease is rheumatoid arthritis.