CALCA and pancreatic ductal adenocarcinoma: Notably, all AKC mice at 8–9 months of age developed pancreatic ductal adenocarcinoma (PDAC) with variable degrees of differentiation, whereas most KC mice exhibited low- or high-grade pancreatic intraepithelial neoplasias (PanINs), of which only 3/10 progressed to PDAC (Supplementary Fig. 4b, e; Table 2).