On the other hand, a study by Kerfant et al. [14] showed that colchicine-induced microtubule disruption can impair calcium handling in ventricular myocytes, potentially predisposing these cells to arrhythmogenesis, also the NLRP3 (NACHT-, LRR- and pyrin domain-containing 3) inflammasome has been implicated in cardiomyocyte-mediated inflammatory signaling, which may contribute to the pathogenesis of AF [15]. The gene discussed is NLRP3; the disease is atrial fibrillation.