UNC5D and hereditary clear cell renal cell carcinoma: UNC5D is under-expressed in renal cell carcinoma (KIRC) due to promoter methylation, which removes EMT inhibition, and co-methylation with NTN1 cooperates with EZH2 to drive metastasis40,46, suggesting that abnormal expression/mutation of NTN1 and its receptor is significantly associated with activation of the EMT pathway, suggesting that it may participate in the regulation of tumor progression.