However, our pan-cancer analysis showed that among the members of the UNC5 family, UNC5D formed the most fusion genes, NEO1 formed fusion genes in various endocrine-associated cancers (OV, BRCA, and PRAD), and some metabolic enzymes with a strong upstream promoter and oncogene functions formed fusion genes with diverse netrin1 receptors. The gene discussed is NEO1; the disease is cancer.