Furthermore, in specialized centers, the expertise of the multidisciplinary team can benefit from the application of the suggested diagnostic workflow which combines a high-performance laboratory test with the experienced clinical assessment of patients, thus being able to classify GIST according to all known molecular subgroups (KIT/PDGFRA/BRAF/NF1/SDHx mutant). Here, PDGFRA is linked to gastrointestinal stromal tumor.