Anyway, to date a laboratory test (commercial or not) that includes the most relevant genes in the management of GISTs (KIT, PDGFRA, SDHx, NF1, BRAF, KRAS, FGFR1) is not available in routine clinical practice, which leads either to missing important genetic information in GIST diagnostics, or to rely on multiple assays or techniques to complete the molecular assessment of the tumor. The gene discussed is BRAF; the disease is gastrointestinal stromal tumor.