Previous studies have shown that RAS enhances cellular \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${{{{\rm{Fe}}}}}^{2+}$$\end{document}Fe2+ levels by upregulating TFR1 expression, thereby increasing the sensitivity of tumor cells to ferroptosis37; conversely, the knockout of TFR1 significantly inhibits ferroptosis induced by erastin or cysteine deprivation38. This evidence concerns the gene TFRC and neoplasm.