GSDMC and cancer: Fourth, DdBIC-induced pyroptosis was associated with GSDMC cleavage in various cancer cell lines (Fig. 1d and Supplementary Fig. 1e), and knockdown of GSDMC suppressed DdBIC-induced pyroptosis in three tumor cell lines (Supplementary Fig. 1f), further suggesting that DdBIC acts as a broad-spectrum inducer of GSDMC-mediated pyroptosis.