However, the knockdown of granzyme B only partially reduced DdBIC-induced LDH release, suggesting that other proteases, including but not limited to granzymes, may compensate for the loss of granzyme B. Together, these findings not only emphasize the function of granzyme B in cancer cells but also provide a new paradigm for triggering pyroptosis via granzyme B cleavage of GSDMC in response to various stimuli. Here, GZMB is linked to cancer.