For example, the synergistic combination of 2-deoxyglucose and hydroxychloroquine induces apoptosis in triple-negative breast cancer cells via the PERK–ATF4–CHOP axis [42], while targeted degradation of STING enhances antitumor immunity by restoring PERK/CHOP-dependent pyroptosis [65]. The gene discussed is DDIT3; the disease is triple-negative breast carcinoma.