EIF2AK3 and triple-negative breast carcinoma: For example, the synergistic combination of 2-deoxyglucose and hydroxychloroquine induces apoptosis in triple-negative breast cancer cells via the PERK–ATF4–CHOP axis [42], while targeted degradation of STING enhances antitumor immunity by restoring PERK/CHOP-dependent pyroptosis [65].