An overlapping set of DEGs in proestrus-only D1-MSNs were broadly associated with neurodegenerative diseases, while those enriched in proestrus-only D2-MSNs were predominantly related to intracellular signaling pathways (PI3K-Akt, MAPK, and Rap1 signaling; Fig. 5C). The gene discussed is AKT1; the disease is neurodegenerative disease.