阿扎胞苷联合来那度胺可有效治疗伴TP53突变MDS患者,安全性和耐受性良好。在治疗有效患者中可显著降低TP53突变VAF。治疗前CBX8基因高表达可能与TP53突变患者治疗起效相关。. The gene discussed is TP53; the disease is myelodysplastic syndrome.