CCL21 and neoplasm: Similarly, after co-incubation with PLIGHT- or PαCD3&LIGHT-transfected tumor cells, the mRNA levels of chemokines and vascular adhesion molecules in vascular endothelial cells, such as CXCL-2, CXCL-8, CXCL-12, CCL-21, MADCAM-1, and VCAM-1, rose by about 2- to 5-fold (Figures S3K–S3P and S3R).