CD8A and neoplasm: For instance, the number of activated CD8+ T cells increased more than 22.52- or 21.71-fold when combined with αPD-L1 or αCTLA-4 (PαCD3&LIGHT + αPD-L1 or PαCD3&LIGHT + αCTLA-4 group) (Figure 5N), and intertumoral cytokine levels were elevated by more than 4-fold (Figures 5P–5R), leading to a substantial increase in apoptotic tumor cells (Figure 5S).