We note that a recent study probing changes in RNA Pol II elongation after short-term inhibition of U2 snRNP with chemical inhibitors suggested that U2 snRNP stabilizes pausing, however our results and those from SF3B1 mutant leukemia cell lines indicate that pause release is more efficient in cells with SF3B1 mutations. The gene discussed is SF3B1; the disease is leukemia.