In this study, we obtained samples from cohorts of long-term ART-suppressed PWH who started ART at acute/early or during chronic infection, from blood donors who tested negative by NAT and nonreactive by serology, and from blood donors who tested positive by NAT and reactive by serology during blood donation screening (presumably untreated infections) to compare the patterns of serologic reactivity as measured and analyze trends over time among PWH after long-term treatment. The gene discussed is BRD2; the disease is infection.