Melanoma cells are capable of simultaneous invasion and division.28 Conditions that induce the invasive phenotype or oppose the proliferative MITF program do not necessitate increased BRN2 expression.29–31 In addition, dependent on the context, MITF and BRN2 can also present reciprocal activation or no relationship at all.21,22,24,29,31–34 Moreover, recent single-cell RNA sequencing studies have expanded the landscape of melanoma cell phenotypes within clonal populations,2–4,35–37 yet these analyses have not reported the BRN2 high phenotype identified by earlier studies. The gene discussed is POU3F2; the disease is melanoma.