POU3F2 and melanoma: Pioneering work in this domain identified two melanoma phenotypes—an MITF-high and BRN2-low proliferative state and an MITF-low and BRN2-high invasive state.23–25,59 Our observations are consistent with a more complex phenotypic landscape.3,4,22,28,31,34,71 First, we observed that the reported MITF-BRN2 bistable switch is present when comparing melanocyte stem cells to DIFF melanocytes.