TNF and psychotic disorder: The psychosis signature distinguished individuals with CHR-P from those with ROP based on a peripheral blood parameter profile of the proinflammatory cytokines IL-6 and TNF-α, as well as CRP—an acute-phase protein considered a nonspecific, indirect marker of low-grade systemic inflammation, albeit with inconsistent findings. Individuals with CHR-P had higher levels of CRP, which could reflect a biological stress response to a changing interaction with and perception of the environment. In contrast, those with ROP had higher IL-6 and TNF-α and lower CRP levels.