TNF and psychotic disorder: Both IL-6 and TNF-α were previously found to be elevated in drug-naive individuals with first-episode psychosis. TNF-α contributes to IL-6 production, which is consistently elevated in psychosis. Moreover, elevated IL-6 alongside lower CRP suggests a shift toward IL-6 transsignaling over classical signaling, previously found to be associated with psychosis risk through reduced membrane-bound receptor expression.