We further demonstrated that genes loading strongly onto CPLF show enriched expression in myofibroblasts, and mechanistically unveiled that its key molecular components, FERMT2 and TNS1, promote tumour progression by enhancing fibronectin 1 (FN1) abundance and activating the integrin-linked kinase/focal adhesion kinase (ILK/FAK) signaling axis. Here, PTK2 is linked to neoplasm.