First generation of tau PET tracers for PSP [103] including 18F-flortaucipir (aka AV1451 or T807), 18F-THK5351, 18F-THK5317, and 11C-PBB3 have shown to selectively target and visualize 4R tau deposits due to off-target binding and inconsistency [103]. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.