More recently, the DAT PET tracer 18F-LBT-999 has been extensively used in rodent and non-human primate models demonstrating its capability to assess dopaminergic presynaptic injury and neuron loss in physiological conditions such as lesion-induced rat models of PD and to evaluate the beneficial effects of therapeutic approaches such as pharmacological treatment and cell transplantation [112]. Here, SLC6A3 is linked to Parkinson disease.