Beyond its role in autophagy, FIP200 has proved to be a versatile molecule: FIP200 interacts with the TSC1-TSC2 complex to regulate cell size (Gan et al., 2005); in ovarian cancer patients, translationally inhibiting FIP200 expression drives high apoptosis in T cells (Xia et al., 2017). The gene discussed is RB1CC1; the disease is ovarian carcinoma.