HMOX1 and malignant colon neoplasm: Hemin is known to induce heme oxygenase-1 (HO-1) expression, which is critical for antiviral effects on SARS-CoV-2 infection, and antitumor effects on prostate, breast, and colon cancer (Andrés et al., 2014; Coló et al., 2023; Gandini et al., 2019; Gueron et al., 2009; Jaworski et al., 2017; Kim et al., 2021; Kodagoda Gamage et al., 2021).