In general, spatial memory impairment in this model of mice appears between 2.5 and 4 months of age [32, 33], while the progressive tau pathology begins at 2.5 months of age and develops neurofibrillary tangles (NFTs), neuronal deficits, and brain atrophy by 6 months of age [34, 35]. The gene discussed is MAPT; the disease is Brain atrophy.