A total of 202 DEGs were identified through pairwise comparisons among the three groups (Wilcoxon rank‐sum test, absolute log2FC ≥.5, p‐value <.05), including 78 upregulated genes and 124 downregulated genes in CD59+ active NK cells of patients with PNH (Figure 3B). The gene discussed is CD59; the disease is paroxysmal nocturnal hemoglobinuria.