Because CPSF5 or CPSF6 depletion is known to induce the use of proximal polyadenylation signals (12, 38, 39, 43, –, 45), we tested the hypothesis that the relocalization of CPSF5 and CPSF6 to nuclear speckles during HIV-1 infection correlates with their functions and leads to APA dysregulation (6). The gene discussed is CPSF6; the disease is HIV-1 infection.