In the human A549 cell line, HIV-1 infection at an MOI of 2 is sufficient to induce CPSF5 and CPSF6 translocation in 80% of cells (42), whereas translocation is only observed in 20% of HeLa cells and 1% of THP-1 cells at an MOI of 2 (42). Here, NUDT21 is linked to HIV-1 infection.