Several roles for CPSF6 during HIV-1 infection have been proposed, including (1) facilitating HIV-1 core entry into the nuclear compartment (8, 16, –, 19), (2) influencing HIV-1 integration and integration site selection (12, 18, 20, –, 22), and (3) assisting with HIV-1 core disassembly (23). This evidence concerns the gene CPSF6 and HIV-1 infection.