To assess whether the change in SLFN5 expression induced by HIV-1 infection also occurs in the main targets of HIV-1, we infected human primary cells, including monocytes, macrophages, and CD4+ T cells with HIV-1-GFP at an MOI of 2 for 96 h and measured SLFN5 protein expression by western blot analysis (Fig. S3A through C). The gene discussed is CD4; the disease is HIV-1 infection.