Unlike the decrease in SLFN5 levels observed with wild-type HIV-1 infection, CPSF5 expression levels in cells infected with HIV-1-A77V were similar to those in mock-infected cells (Fig. 6C), suggesting that HIV-1 infection specifically alters cellular expression patterns through the interaction of the viral capsid with CPSF6. The gene discussed is SLFN5; the disease is HIV-1 infection.