Albumin‐bilirubin scores worsened progressively, according to the criteria (−2.70/−2.54/−2.40/−2.37), and elevated tumor marker levels (alpha‐fetoprotein [AFP] levels ≥ 100 ng/mL: 18.5%/35.8%/46.5%/59.5%; AFP‐L3 ≥ 10%: 19.8%/40.9%/54.7%/66.7%; and des‐gamma‐carboxy prothrombin levels ≥ 100 mAU/mL: 35.8%/67.4%/81.4%/90.5%, each p < 0.001) occurred more frequently in advanced groups. The gene discussed is F2; the disease is neoplasm.