A recent study demonstrated that epididymal fat cell size was significantly reduced in SEMA‐treated male mice with metabolic syndrome (Estato et al. 2025), and earlier work showed that GLP‐1 treatment reduced adipocyte size in epididymal fat of ob/ob mice (Lee et al. 2012), highlighting the drug's capacity to directly influence adipocyte morphology. The gene discussed is GLP1R; the disease is metabolic syndrome.