Additionally, immunoprecipitation (IP) assays in HEV-infected HepG2/C3A cells and S10-3 cells transfected with HEV RNA demonstrated that GRP75 interacted with HEV-ORF2 during viral infection in permissive cells (Fig. 2C and D), providing strong evidence that GRP75 is an interacting partner of HEV-ORF2 during HEV infection. The gene discussed is HSPA9; the disease is viral infectious disease.