We also identified the top 1 GEAR in individual cancer types, such as TLL1 (BLCA), PGK1 (BRCA), RFXANK (CESC), DPP7 (COAD), VWA8 (KIRC), SCMH1 (LGG), HILPDA (LIHC), TLE1 (LUAD), CD151 (LUSC), ANKRD13A (OV), SOCS2 (PAAD), DRG2 (PRAD), ADAMTS6 (STAD), PSMB8 (THCA), ASS1 (UCEC) (Supplementary file 1C). The gene discussed is SOCS2; the disease is cancer.