TAR DNA‐binding protein 43 (TDP‐43) aggregation is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), PD, frontotemporal dementia (FTD), AD and limbic predominant age‐related TDP‐43 encephalopathy (LATE). The gene discussed is TARDBP; the disease is Alzheimer disease.