PLIN2 and Parkinson disease: While canonical LDs are typically characterized by the presence of specific associated proteins such as PLIN2 and PLIN3 (Conte et al., 2022), the PLIN2-negative lipid inclusions reported in PD (Brekk et al., 2020) could reflect recruitment of alternative brain-enriched PLIN isoforms (e.g., PLIN3 or PLIN5), impaired LD-associated protein recruitment, or accumulation of non-mature LDs.