SMAD4 and renal cell carcinoma: Other associated TFs include SMAD4 (P = 1.2×10−8), EP300 (minimum p-value = 5.4×10−7), TAF1 (P = 1.3×10−6), and KAT6A (P = 2.8×10−6), all of which have been implicated in processes related to multiple cancers47–51 and might represent candidate master regulators that integrate upstream risk signals to drive aberrant tumorigenic processes and in particular, RCC development.