In particular, JMJD6 which was assayed both in tumor as well as normal-like cell lines, exhibited association only in tumor cell line 786-O but not in normal embryonic cell line HEK293 (P = 0.04) indicating that the variants at its binding sites, specifically in tumors, has a significant aggregated effect on ccRCC. Here, JMJD6 is linked to nonpapillary renal cell carcinoma.