TF and renal cell carcinoma: Of the 103 RCC-TF associations, 83 (80.58%) remained significant within “consensus peaks” of H3K4me2, which marks regulatory elements poised for or engaged in transcriptional activity, while 91 (88.35%) remained significant when restricted to “consensus peaks” for H3K27ac, a marker of active regulatory elements, particularly enhancers (Figure 2B), with 77 (74.8%) associations significant in both (Supplementary Table 5).