In this study, we conducted a genomic and epigenomic analysis to identify the TFs and potential target proteins driving RCC susceptibility using the largest GWAS of RCC and its subtypes to date7, coupled with publicly available chromatin immunoprecipitation followed by high throughput sequencing (ChIP-seq) data from 449 TF ChIP-seq experiments across diverse kidney-related cell types36,37. This evidence concerns the gene TF and renal cell carcinoma.