SMARCA4 and renal cell carcinoma: In particular, in the TTC1240 cell line SMARCA4, a core ATPase component of the SWI/SNF chromatin remodeling complex, showed notable stronger associations at both consensus H3K4me2 (P = 2.3×10−17) and H3K27ac peaks (P = 5.3×10−18) compared to previous analysis of only ChIP-seq peaks (P = 6.2×10−05), highlighting its regulatory potential in RCC (Figure 2D).