In particular for ccRCC, we identified significant interactions of PBRM1 with SMARCA4 (P = 2.5×10−4) and SMARCC2 (P = 7.1×10−5) in the G-401 cell line, all known members of SWI/SNF complexes and known to regulate transcriptional responses to hypoxia by modulating chromatin accessibility at HIF target genes. The gene discussed is PBRM1; the disease is nonpapillary renal cell carcinoma.