• BMI ≥27 with Comorbidities: Consider GLP-1 receptor agonists (e.g., semaglutide) as an adjunct.• Severe Obesity/Resistant HTN: Evaluate for metabolic surgery (e.g., Roux-en-Y Gastric Bypass).• Children/Adolescents: Integrate family-based behavioral interventions. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.