GLP1R and Insulin resistance: Enhanced lifestyle modifications, encompassing a heart-healthy diet, regular physical activity, and smoking cessation, constitute a potent “multi-targeted therapy” capable of simultaneously improving insulin resistance, lowering blood pressure, reducing weight, regulating lipids, and alleviating inflammation (96).When medications are available, priority should be given to novel agents with established organ-protective evidence, such as SGLT2 inhibitors, GLP-1 receptor agonists, and finerenone, to ensure precise targeting of distinct phenotypes.