The results showed that the AUC of the combination of HMOX1 mRNA and imaging parameters was 0.871 (95% CI: 0.818 – 0.924), which was significantly higher than that of hemorrhage location alone (AUC = 0.630, 95% CI: 0.552 – 0.707; AUC difference = 0.241, P < 0.001), hematoma volume alone (AUC = 0.657, 95% CI: 0.583 – 0.731; AUC difference = 0.214, P < 0.001), and HMOX1 mRNA alone (AUC = 0.775, 95% CI: 0.708 – 0.843; AUC difference = 0.096, P = 0.012) (Figure 3a, Table 4). This evidence concerns the gene HMOX1 and hemorrhage.