Despite being known for its potential among other PLK types (PLK2, PLK3, PLK4, and PLK5), PLK1 is determined recently as a potential oncogenic target across various cancer types due to its extensive research exploration and essential mitotic roles (Fang et al., 2022; Jiawei et al., 2022; Garlapati et al., 2023; Guerrero-Zotano et al., 2023). Here, PLK5 is linked to cancer.