Inhibits digestive enzymes, modulates neurohormones, improves gut microbes, boosts BAT activity, inhibits fat formation (Wnt, Rb), alleviates insulin resistance (PI3K/AKT, STAT3), anti-inflammatory (COX-1, COX-2, MMP), attenuates muscle atrophy (p38 MAPK, ubiquitination), mitochondrial protection. This evidence concerns the gene RB1 and Insulin resistance.