PHLPP1 and stroke disorder: The top signal in the African ancestry stroke GWAS24 is chr18:60380912 (rs73465039, effect allele = T, other allele = G, effect allele frequency = .06, β = 0.22, P = 1.80×10−4), which shows strong support from nearby SNPs in the promoter region of PHLPP1 (Figure 1B).