PHLPP1 and Alzheimer disease: Analysis of chromatin interactions with the top hits from the African ancestry AD and stroke GWAS indicate that the two regions carrying the disease associated haplotypes interact with each other in the PHLPP1 gene: the stroke top hit shows strong chromatin interaction with the genomic region in the 3’ end of the gene where the AD top is located, and the AD top hit shows strong chromatin interaction with the genomic region in the 5’ end of the gene where the stroke top hit is located (Figure 2).