PHLPP1 and Alzheimer disease: The top signal in the African ancestry AD GWAS23 is chr18:60662938 (rs512453, effect allele = T, other allele = C, effect allele frequency = .90, β = 0.25, P = 6.02×10−5), which is located on the 3’ end of PHLPP1 and shows strong support from nearby SNPs (Figure 1A).