Compared to prior APOE*4 stratified AD GWAS by Jun et al. and Madrid et al. 56,57, in which effective sample sizes ranged 18,130–23,412 in respective APOE*4 strata, our GWAS was better powered with effective sample sizes of 38,608 and 50,752 in APOE*4+ and APOE*4− subjects, respectively. Here, APOE is linked to Alzheimer disease.