Looking into the complicated relationship between the KISS1 gene, kisspeptin, the GPR54 receptor pathway, and the HPG axis, we have tried to identify the polymorphisms in the KISS1 gene and examine the association between KISS1 gene polymorphisms and serum kisspeptin levels, LH, FSH, the LH-FSH ratio, and WHR in women with PCOS and controls. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.